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Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women
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Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women
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Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women
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Journal Article
Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women
2017
Overview
Background
To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide,
Coriolus versicolor
,
Asian centella
,
Azadirachta indica
and
Aloe vera
on vaginal microbiota, cervical epithelization and vaginal health.
Methods
Open-label, prospective pilot study conducted in asymptomatic women in daily practice. Cervical epithelization was evaluated by colposcopy using an ectopy epithelization score (from 5: no ectopy to 1: severe ectopy and bleeding), vaginal microbiota using the VaginaStatus-Diagnostic test (Instiüt für Mikroökologie, Herborn, Germany) and further rated by the investigator using a 5-point Liker scale (from 5: normal to 1: very severe deterioration in which all evaluated species were altered), and vaginal health using the Vaginal Health Index.
Results
In 21 women, a positive effect to improve epithelization of the cervical mucosa, with a mean score of 4.42 at the final visit as compared to 3.09 at baseline (
P
< 0.0001) (43% improvement). In 10 women, there was a trend of improving of vaginal microbiota status, with a mean score of 4.0 at the final visit vs. 3.3 at baseline (
P
= NS) (21.2% improvement). In 11 women, the Vaginal Health Index increased from 19.0 at baseline to 22.3 at the final visit (
P
= 0.007). The concentration of
Lactobacillus
spp. increased 54.5% of women and pH decreased from 4.32 to 4.09.
Conclusions
These encouraging preliminary results provide the basis for designing a randomized controlled study, and for potential use in human papilloma virus infection.
Trial registration
ISRCTN77955077
. Registration date: February 15, 2017. Retrospectively registered
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
/ Data Interpretation, Statistical
/ Female
/ Humans
/ Lactobacillus - growth & development
/ Medicine
/ Microbiota (Symbiotic organisms)
/ Spain
/ Vaginal Creams, Foams, and Jellies - administration & dosage
/ Vaginal Creams, Foams, and Jellies - pharmacology
