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Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition
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Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition
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Journal Article
Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition
2025
Overview
Aberrant glycosylation, especially sialylation, on cell surface is often associated with cancer progression and immunosuppression. Over-sialylation of stage-specific embryonic antigen-4 (SSEA-4) to generate disialylGb5 (DSGb5) was reported to trigger Siglec-7 recognition and suppress NK-mediated target killing. In this study, efficient chemo-enzymatic and programmable one-pot methods were explored for the synthesis of DSGb5 and related sialosides for assembly of glycan microarrays and evaluation of binding specificity toward Siglecs-7, 9, 10, and 15 associated with immune checkpoint inhibition. The result showed weak binding of DSGb5 to these Siglecs; however, a truncated glycolyl glycan was identified to bind Siglec-10 strongly with a dissociation constant of 50 nM and exhibited a significant inhibition of Siglec-10 interacting with breast cancer cells.
Publisher
MDPI AG,MDPI
Subject
/ Antigens
/ Antigens, Differentiation, Myelomonocytic
/ Cancer
/ Enzymes
/ Humans
/ Immune Checkpoint Inhibitors - chemical synthesis
/ Immune Checkpoint Inhibitors - chemistry
/ Immune Checkpoint Inhibitors - pharmacology
/ Kinases
/ Sialic Acid Binding Immunoglobulin-like Lectins - chemistry
/ Sialic Acid Binding Immunoglobulin-like Lectins - metabolism
