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Comparison of Two Fluid-Management Strategies in Acute Lung Injury
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Comparison of Two Fluid-Management Strategies in Acute Lung Injury
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Journal Article
Comparison of Two Fluid-Management Strategies in Acute Lung Injury
2006
Overview
One of the characteristics of acute lung injury is noncardiogenic pulmonary edema. Arguments have been made for the management of acute lung injury with either a liberal or conservative approach to fluid administration. In this trial, neither approach offered a mortality benefit; there were clinical and physiological benefits to conservative fluid management.
Arguments have been made for the management of acute lung injury with either a liberal or conservative approach to fluid administration. In this trial, neither approach offered a mortality benefit; there were clinical and physiological benefits to conservative fluid management.
Pulmonary edema resulting from increased capillary permeability, a hallmark of acute lung injury, worsens as intravascular hydrostatic pressure rises and oncotic pressure falls.
1
,
2
Although lung failure alone can be lethal, death in patients with acute lung injury is usually due to the failure of nonpulmonary organs.
1
,
3
The optimal fluid management of acute lung injury is not settled.
4
–
7
The usual practice is wide-ranging, and many practitioners weigh the risks and benefits of strategies of conservative as compared with liberal fluid management. In the conservative approach, fluid intake is restricted and urinary output is increased in an attempt to . . .
Publisher
Massachusetts Medical Society
Subject
Biological and medical sciences
/ Female
/ Fluid Therapy - adverse effects
/ Furosemide - therapeutic use
/ Humans
/ Injuries
/ Intensive Care Units - utilization
/ Lungs
/ Male
/ Proteins
/ Respiration, Artificial - utilization
/ Respiratory distress syndrome
/ Respiratory Distress Syndrome, Adult - mortality
/ Respiratory Distress Syndrome, Adult - physiopathology
