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Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium
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Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium
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Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium
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Journal Article
Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium
2017
Overview
Background
Mammographic breast density is a well-established strong risk factor for breast cancer. The environmental contributors to geographic variation in breast density in urban and rural areas are poorly understood. We examined the association between breast density and exposure to ambient air pollutants (particulate matter <2.5 μm in diameter (PM
2.5
) and ozone (O
3
)) in a large population-based screening registry.
Methods
Participants included women undergoing mammography screening at imaging facilities within the Breast Cancer Surveillance Consortium (2001–2009). We included women aged ≥40 years with known residential zip codes before the index mammogram (
n
= 279,967). Breast density was assessed using the American College of Radiology’s Breast Imaging-Reporting and Data System (BI-RADS) four-category breast density classification. PM
2.5
and O
3
estimates for grids across the USA (2001–2008) were obtained from the US Environmental Protection Agency Hierarchical Bayesian Model (HBM). For the majority of women (94%), these estimates were available for the year preceding the mammogram date. Association between exposure to air pollutants and density was estimated using polytomous logistic regression, adjusting for potential confounders.
Results
Women with extremely dense breasts had higher mean PM
2.5
and lower O
3
exposures than women with fatty breasts (8.97 vs. 8.66 ug/m
3
and 33.70 vs. 35.82 parts per billion (ppb), respectively). In regression analysis, women with heterogeneously dense vs. scattered fibroglandular breasts were more likely to have higher exposure to PM
2.5
(fourth vs. first quartile odds ratio (OR) = 1.19, 95% confidence interval (CI) 1.16 − 1.23). Women with extremely dense vs. scattered fibroglandular breasts were less likely to have higher levels of ozone exposure (fourth vs. first quartile OR = 0.80, 95% CI 0.73–0.87).
Conclusion
Exposure to PM
2.5
and O
3
may in part explain geographical variation in mammographic density. Further studies are warranted to determine the causal nature of these associations.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
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