Asset Details
Do you wish to reserve the book?
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
Do you wish to request the book?
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
2010
Overview
Hematopoietic stem cells infrequently proliferate, but their self-renewal is essential. Aifantis and colleagues show regulation of c-Myc protein stability by the ubiquitin ligase Fbw7 controls the self-renewal and differentiation potential of these cells.
Hematopoietic stem cell (HSC) differentiation is regulated by cell-intrinsic and cell-extrinsic cues. In addition to transcriptional regulation, post-translational regulation may also control HSC differentiation. To test this hypothesis, we visualized the ubiquitin-regulated protein stability of a single transcription factor, c-Myc. The stability of c-Myc protein was indicative of HSC quiescence, and c-Myc protein abundance was controlled by the ubiquitin ligase Fbw7. Fine changes in the stability of c-Myc protein regulated the HSC gene-expression signature. Using whole-genome genomic approaches, we identified specific regulators of HSC function directly controlled by c-Myc binding; however, adult HSCs and embryonic stem cells sensed and interpreted c-Myc-regulated gene expression in distinct ways. Our studies show that a ubiquitin ligase–substrate pair can orchestrate the molecular program of HSC differentiation.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Cell Cycle Proteins - immunology
/ Cell Differentiation - genetics
/ Cell Differentiation - physiology
/ Chromatin Immunoprecipitation
/ Hematopoietic Stem Cells - cytology
/ Hematopoietic Stem Cells - immunology
/ Hematopoietic Stem Cells - metabolism
/ Ligases
/ Mice
