Journal Article

Development and validation of a risk prediction score for severe acute pancreatitis

Kontopantelis, Evangelos, Zimmer, Vincent, Wang, Chao, Stock, Simon, Pan, Shuang, Zippi, Maddalena, Lillemoe, Keith D., Hong, Wandong, Zhou, Mengtao

2019

Overview

Introduction The available prognostic scoring systems for severe acute pancreatitis (SAP) have limitations that restrict their clinical value. The aim of this study was to develop a simple model (score) that could rapidly identify those at risk for SAP. Methods We derived a risk model using a retrospective cohort of 700 patients by logistic regression and bootstrapping methods. The discriminative power of the risk model was assessed by calculating the area under the receiver operating characteristic curves (AUC). The classification and regression tree (CART) analysis was used to create risk categories. The model was internally validated by a tenfold cross-validation and externally validated in a separate prospective cohort of 194 patients. Results The incidence of SAP was 9.7% in the derivation cohort and 9.3% in the validation cohort. A prognostic score (We denoted it as the SABP score), ranging from 0 to 10, consisting of systemic inflammatory response syndrome, serum albumin, blood urea nitrogen and pleural effusion, was developed by logistic regression and bootstrapping analysis. Patients could be divided into three risk categories according to total SABP score based on CART analysis. The mean probability of developing SAP was 1.9%, 12.8% and 41.6% in patients with low (0–3), moderate (4–6) and high (7–10) SABP score, respectively. The AUCs of prognostic score in tenfold cross-validation was 0.873 and 0.872 in the external validation. Conclusion Our risk prediction score may assist physicians in predicting the development of SAP.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acute Disease / Acute pancreatitis / Adult / Albumin / Biomedical and Life Sciences / Biomedicine / Body mass index / Cohort Studies / Data collection / Data-driven Clinical Decision Processes / Diagnosis / Disease / Disease biomarkers / Effusion / Endoscopy / Female / Heart failure / Hospitals / Humans / Inflammation / Male / Medicine/Public Health / Middle Aged / Mortality / Multivariate Analysis / Nitrogen / Pancreatitis / Pancreatitis - diagnosis / Physicians / Pleural effusion / Prediction / Reproducibility of Results / Risk Assessment / Risk factor / Risk Factors / ROC Curve / Score / Sepsis / Severity / Severity of Illness Index / Surveillance / Systemic inflammatory response syndrome / Urea / Variables