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Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema
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Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema
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Journal Article
Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema
2022
Overview
Purpose
Breast cancer treatment-related lymphedema (BCRL) is a common co-morbidity of breast cancer therapies, yet factors that contribute to BCRL progression remain incompletely characterized. We investigated whether magnetic resonance imaging (MRI) measures of subcutaneous adipose tissue were uniquely elevated in women with BCRL.
Methods
MRI at 3.0 T of upper extremity and torso anatomy, fat and muscle tissue composition, and
T
2
relaxometry were applied in left and right axillae of healthy control (
n
= 24) and symptomatic BCRL (
n
= 22) participants to test the primary hypothesis that fat-to-muscle volume fraction is elevated in symptomatic BCRL relative to healthy participants, and the secondary hypothesis that fat-to-muscle volume fraction is correlated with MR relaxometry of affected tissues and BCRL stage (significance criterion: two-sided
p
< 0.05).
Results
Fat-to-muscle volume fraction in healthy participants was symmetric in the right and left sides (
p
= 0.51); in BCRL participants matched for age, sex, and BMI, fat-to-muscle volume fraction was elevated on the affected side (fraction = 0.732 ± 0.184) versus right and left side in controls (fraction = 0.545 ± 0.221,
p
< 0.001). Fat-to-muscle volume fraction directly correlated with muscle
T
2
(
p
= 0.046) and increased with increasing level of BCRL stage (
p
= 0.041).
Conclusion
Adiposity quantified by MRI is elevated in the affected upper extremity of women with BCRL and may provide a surrogate marker of condition onset or severity.
Clinical trial
NCT02611557.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Adipose Tissue - diagnostic imaging
/ Body fat
/ Breast Cancer Lymphedema - diagnostic imaging
/ Breast Cancer Lymphedema - etiology
/ Breast Cancer Lymphedema - therapy
/ Breast Neoplasms - complications
/ Breast Neoplasms - diagnostic imaging
/ Cancer
/ Female
/ Humans
/ Lymphedema - diagnostic imaging
/ Medicine
/ NCT
/ Oncology
/ Women
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