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Ganoderma immunomodulatory proteins: mushrooming functional FIPs
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Journal Article
Ganoderma immunomodulatory proteins: mushrooming functional FIPs
2022
Overview
Fungal immunomodulatory protein (FIP) is a novel functional protein family with specific immunomodulatory activity identified from several macro-fungi. A variety of biological activities of FIPs have been reported, such as anti-allergy, anti-tumor, mitogenic activity, and immunomodulation. Among all known FIPs, the firstly discovered FIP was isolated from
Ganoderma lucidum
, and most FIP members were from
Ganoderma
genus. Compared with other FIPs,
Ganoderma
FIPs possess some advantageous bioactivities, like stronger anti-tumor activity. Therein, gene sequences, protein structural features, biofunctions, and recombinant expression of
Ganoderma
FIPs were summarized and addressed, focusing on elucidating their anti-tumor activity and molecular mechanisms. Combined with current advances, development potential and application of
Ganoderma
FIPs were also prospected.
Key points
•
More than a dozen of reported FIPs are identified from Ganoderma species.
•
Ganoderma immunomodulatory proteins have superior anti-tumor activity with promising prospects and application.
•
Current review comprehensively addresses characterization, biofunctions, and anti-tumor mechanisms of Ganoderma FIPs.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
