Asset Details
Do you wish to reserve the book?
Extreme slow growth as alternative strategy to survive deep starvation in bacteria
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Extreme slow growth as alternative strategy to survive deep starvation in bacteria
Do you wish to request the book?
Extreme slow growth as alternative strategy to survive deep starvation in bacteria
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Extreme slow growth as alternative strategy to survive deep starvation in bacteria
2019
Overview
Bacteria can become dormant or form spores when they are starved for nutrients. Here, we find that non-sporulating
Bacillus subtilis
cells can survive deep starvation conditions for many months. During this period, cells adopt an almost coccoid shape and become tolerant to antibiotics. Unexpectedly, these cells appear to be metabolically active and show a transcriptome profile very different from that of stationary phase cells. We show that these starved cells are not dormant but are growing and dividing, albeit with a doubling time close to 4 days. Very low nutrient levels, comparable to 10,000-fold diluted lysogeny broth (LB), are sufficient to sustain this growth. This extreme slow growth, which we propose to call ‘oligotrophic growth state’, provides an alternative strategy for
B. subtilis
to endure nutrient depletion and environmental stresses. Further work is warranted to test whether this state can be found in other bacterial species to survive deep starvation conditions.
Bacteria can become dormant or form spores when starved for nutrients. Here, Gray et al. describe an alternative strategy, or ‘oligotrophic growth state’, showing that non-sporulating
Bacillus subtilis
cells can survive deep starvation conditions by adopting an almost coccoid shape and extremely low growth rates.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
