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Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research
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Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research
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Journal Article
Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research
2021
Overview
Gene regulatory elements are central drivers of phenotypic variation and thus of critical importance towards understanding the genetics of complex traits. The Functional Annotation of Animal Genomes consortium was formed to collaboratively annotate the functional elements in animal genomes, starting with domesticated animals. Here we present an expansive collection of datasets from eight diverse tissues in three important agricultural species: chicken (
Gallus gallus
), pig (
Sus scrofa
), and cattle (
Bos taurus
). Comparative analysis of these datasets and those from the human and mouse Encyclopedia of DNA Elements projects reveal that a core set of regulatory elements are functionally conserved independent of divergence between species, and that tissue-specific transcription factor occupancy at regulatory elements and their predicted target genes are also conserved. These datasets represent a unique opportunity for the emerging field of comparative epigenomics, as well as the agricultural research community, including species that are globally important food resources.
In order to interpret non-coding variants, information about regulatory elements in the genome is essential. Here, the authors annotate regulatory elements in chicken, pig and cattle, and characterize conservation of these elements between species.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/22
/ 45/23
/ 45/90
/ 45/91
/ Animals
/ Animals, Domestic - genetics
/ Cattle
/ Chickens
/ Chromatin Immunoprecipitation Sequencing
/ Datasets
/ DNA
/ Enhancer Elements, Genetic - genetics
/ Gene Expression Regulation - genetics
/ Genetics
/ Genome-Wide Association Study
/ Genomes
/ Humanities and Social Sciences
/ Mice
/ Organ Specificity - genetics
/ Polymorphism, Single Nucleotide
/ Regulatory Sequences, Nucleic Acid - genetics
/ Science
/ Transcription Factors - genetics
