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The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
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The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
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Journal Article
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
2020
Overview
The pathophysiological nature of the common
ABCG2
gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K
ABCG2
variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. We explore mechanisms by generating a mouse model of the orthologous Q140K
Abcg2
variant and find male mice have significant hyperuricemia and metabolic alterations, but only subtle alterations of renal urate excretion and ABCG2 abundance. By contrast, these mice display a severe defect in ABCG2 abundance and function in the intestinal tract. These results suggest a tissue specific pathobiology of the Q141K variant, support an important role for ABCG2 in urate excretion in both the human kidney and intestinal tract, and provide insight into the importance of intestinal urate excretion for serum urate homeostasis.
The common
ABCG2
variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/51
/ 64
/ 64/60
/ 692/4022
/ 82/80
/ Alleles
/ Animals
/ ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics
/ ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism
/ Glucose Transport Proteins, Facilitative - genetics
/ Glucose Transport Proteins, Facilitative - metabolism
/ Gout
/ Humanities and Social Sciences
/ Humans
/ Kidneys
/ Load
/ Male
/ Mice
/ Proteins
/ Science
