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Target specific functions of EPL interneurons in olfactory circuits
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Target specific functions of EPL interneurons in olfactory circuits
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Journal Article
Target specific functions of EPL interneurons in olfactory circuits
2019
Overview
Inhibitory interneurons are integral to sensory processing, yet revealing their cell type-specific roles in sensory circuits remains an ongoing focus. To Investigate the mouse olfactory system, we selectively remove GABAergic transmission from a subset of olfactory bulb interneurons, EPL interneurons (EPL-INs), and assay odor responses from their downstream synaptic partners — tufted cells and mitral cells. Using a combination of in vivo electrophysiological and imaging analyses, we find that inactivating this single node of inhibition leads to differential effects in magnitude, reliability, tuning width, and temporal dynamics between the two principal neurons. Furthermore, tufted and not mitral cell responses to odor mixtures become more linearly predictable without EPL-IN inhibition. Our data suggest that olfactory bulb interneurons, through exerting distinct inhibitory functions onto their different synaptic partners, play a significant role in the processing of odor information.
The precise cell-type specific role of inhibitory interneurons in regulating sensory responses in the olfactory bulb is not known. Here, the authors report that removing GABAergic inhibition from one layer differentially affects response dynamics of the two main output cell types and changes odor mixture processing.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/69
/ 38
/ 38/1
/ 38/39
/ 42/44
/ 64/60
/ 9/74
/ Animals
/ Circuits
/ Humanities and Social Sciences
/ Neural Inhibition - genetics
/ Neural Inhibition - physiology
/ Odor
/ Odorants
/ Odors
/ Olfactory Pathways - physiology
/ Science
/ Smell
/ Synaptic Transmission - genetics
