Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
by
Taniguchi, Hirokazu
, Wang, Wei
, Kita, Kenji
, Matsumoto, Kunio
, Yamashita, Kaname
, Uehara, Hisanori
, Ishimura, Akihiko
, Atagi, Shinji
, Ohtsubo, Koshiro
, Yamano, Tomoyoshi
, Arai, Sachiko
, Yamada, Tadaaki
, Terashima, Minoru
, Tanimoto, Azusa
, Suzuki, Takeshi
, Taniguchi, Yoshihiko
, Yoshimura, Akihiro
, Wang, Rong
, Matsumoto, Isao
, Nishiyama, Akihiro
, Kaira, Kyoichi
, Han, Xujun
, Fukuda, Koji
, Takeuchi, Shinji
, Yano, Seiji
, Takayama, Koichi
, Hanayama, Rikinari
in
Acrylamides - pharmacology
/ Acrylamides - therapeutic use
/ Activation
/ Adaptor proteins
/ Aged, 80 and over
/ Aniline Compounds - pharmacology
/ Aniline Compounds - therapeutic use
/ Animals
/ Axl protein
/ Carcinoma, Non-Small-Cell Lung - drug therapy
/ Carcinoma, Non-Small-Cell Lung - genetics
/ Carcinoma, Non-Small-Cell Lung - pathology
/ Cell Line, Tumor
/ Cell Survival - drug effects
/ Drug tolerance
/ Epidermal growth factor
/ Epidermal growth factor receptors
/ ErbB Receptors - genetics
/ Gene Expression Regulation, Neoplastic - drug effects
/ Growth factors
/ Hepatocyte Nuclear Factor 3-alpha - metabolism
/ Humans
/ Imidazoles - pharmacology
/ Immunological tolerance
/ Inhibitors
/ Insulin
/ Insulin-like growth factor I
/ Insulin-like growth factors
/ Kinases
/ Lung cancer
/ Lung Neoplasms - drug therapy
/ Lung Neoplasms - genetics
/ Lung Neoplasms - pathology
/ Male
/ Mice
/ Models, Biological
/ Mutation - genetics
/ Phosphorylation
/ Phosphorylation - drug effects
/ Protein-tyrosine kinase
/ Proto-Oncogene Proteins - metabolism
/ Pyrazines - pharmacology
/ Receptor Protein-Tyrosine Kinases - metabolism
/ Receptor, IGF Type 1 - antagonists & inhibitors
/ Receptor, IGF Type 1 - genetics
/ Receptor, IGF Type 1 - metabolism
/ Receptors
/ Regrowth
/ Resistance factors
/ RNA, Messenger - genetics
/ RNA, Messenger - metabolism
/ Signal transduction
/ Targeted cancer therapy
/ Tumors
/ Tyrosine
/ Up-Regulation - drug effects
/ Xenografts
/ Xenotransplantation
2020