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Oxytocin pathway gene networks in the human brain
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Journal Article
Oxytocin pathway gene networks in the human brain
2019
Overview
Oxytocin is a neuropeptide involved in animal and human reproductive and social behavior. Three oxytocin signaling genes have been frequently implicated in human social behavior:
OXT
(structural gene for oxytocin),
OXTR
(oxytocin receptor), and
CD38
(oxytocin secretion). Here, we characterized the distribution of
OXT
,
OXTR
, and
CD38
mRNA across the human brain by creating voxel-by-voxel volumetric expression maps, and identified putative gene pathway interactions by comparing gene expression patterns across 20,737 genes. Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions. fMRI meta-analysis revealed that the oxytocin pathway gene maps correspond with the processing of anticipatory, appetitive, and aversive cognitive states. The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.
Oxytocin is a hormone and neurotransmitter involved in reproductive and social behavior, but the role of oxytocin-related genes in the human brain remains unclear. Here, the authors map oxytocin pathway gene expression and show that it overlaps with brain regions involved in reward and emotional states.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
