Asset Details
Do you wish to reserve the book?
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
Do you wish to request the book?
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
2019
Overview
A long-standing question in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factors, allowing normal early embryonic development. We have previously shown that N6-methyladenine (6mA) DNA modification is highly dynamic in early
Drosophila
embryos and forms an epigenetic mark. However, little is known about how 6mA-formed epigenetic information is decoded. Here we report that the Fox-family protein Jumu binds 6mA-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition. We find that
zelda
encoding the pioneer factor Zelda is marked by 6mA. Our genetic assays suggest that Jumu controls the proper zygotic genome activation (ZGA) in early embryos, at least in part, by regulating
zelda
expression. Thus, our findings not only support that the 6mA-formed epigenetic marks can be read by specific transcription factors, but also uncover a mechanism by which the Jumu regulates ZGA partially through Zelda in early embryos.
N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked pioneer factor zelda.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45
/ 631/136
/ Adenine - analogs & derivatives
/ Animals
/ Animals, Genetically Modified
/ DNA
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Embryonic Development - physiology
/ Embryos
/ Epigenesis, Genetic - physiology
/ Female
/ Gene Expression Regulation, Developmental - physiology
/ Genomes
/ Humanities and Social Sciences
/ Male
/ Science
/ Transcription Factors - genetics
