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The global distribution and spread of the mobilized colistin resistance gene mcr-1
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Journal Article
The global distribution and spread of the mobilized colistin resistance gene mcr-1
2018
Overview
Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant
Enterobacteriaceae
. As such, the recent plasmid-mediated spread of the colistin resistance gene
mcr-1
poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of
mcr-1
using a data set of 457
mcr-1-
positive sequenced isolates. We find
mcr-1
in various plasmid types but identify an immediate background common to all
mcr-1
sequences. Our analyses establish that all
mcr-1
elements in circulation descend from the same initial mobilization of
mcr-1
by an IS
A
pl1
transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of
mcr-1
, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.
The recent plasmid-mediated spread of the mobilized colistin resistance gene
mcr-1
poses a significant public health threat, requiring worldwide monitoring and surveillance. Here, Wang et al. compile and analyze a data set of 457
mcr-1
-positive sequenced isolates to investigate the origin and global distribution of
mcr-1
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ 631/114
/ 631/326
/ Anti-Bacterial Agents - pharmacology
/ Colistin
/ Datasets
/ Drug Resistance, Multiple, Bacterial - genetics
/ Enterobacteriaceae - classification
/ Enterobacteriaceae - drug effects
/ Enterobacteriaceae - genetics
/ Enterobacteriaceae - isolation & purification
/ Enterobacteriaceae Infections - epidemiology
/ Enterobacteriaceae Infections - microbiology
/ Enterobacteriaceae Infections - transmission
/ Escherichia coli Proteins - genetics
/ Escherichia coli Proteins - metabolism
/ Genes
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Metadata
/ Plasmids
/ Science
