Asset Details
Do you wish to reserve the book?
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Do you wish to request the book?
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
2018
Overview
Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA
H19
increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of
H19
with BMI were also observed in humans.
H19
overexpression promoted, while silencing of
H19
impaired adipogenesis, oxidative metabolism and mitochondrial respiration in brown but not white adipocytes. In vivo,
H19
overexpression protected against DIO, improved insulin sensitivity and mitochondrial biogenesis, whereas fat
H19
loss sensitized towards HFD weight gains. Strikingly, paternally expressed genes (PEG) were largely absent from BAT and we demonstrated that
H19
recruits PEG-inactivating
H19
-MBD1 complexes and acts as BAT-selective PEG gatekeeper. This has implications for our understanding how monoallelic gene expression affects metabolism in rodents and, potentially, humans.
Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/109
/ 38/39
/ 38/91
/ 45/88
/ 64/60
/ Adipose Tissue, Brown - pathology
/ Adipose Tissue, Brown - physiology
/ Adipose Tissue, White - physiology
/ Adult
/ Aged
/ Animals
/ Diet, High-Fat - adverse effects
/ Energy Metabolism - genetics
/ Female
/ Genes
/ Humanities and Social Sciences
/ Humans
/ Insulin
/ Male
/ Obesity
/ RNA, Long Noncoding - genetics
/ Rodents
/ Science
/ Weight
We currently cannot retrieve any items related to this title. Kindly check back at a later time.