Journal Article

The risk factors of local recurrence and distant metastasis on pT1/T2N0 mid-low rectal cancer after total mesorectal excision

Tsai, Wen-Sy, Chern, Yih-Jong, Lai, I-Li, Hsieh, Pao-Shiu, Hsu, Yu-Jen, Hung, Hsin-Yuan, You, Jeng-Fu, Chiang, Jy-Ming

2021

Overview

Background Radical resection is associated with good prognosis among patients with cT1/T2Nx rectal cancer. However, still some of the patients experienced cancer recurrence following radical resection. This study tried to identify the postoperative risk factors of local recurrence and distant metastasis separately. Methods This retrospective, single-center study comprised of 279 consecutive patients from Linkou branch of Chang Gung Memorial Hospital in 2005–2016 with rectal adenocarcinoma, pT1/T2N0M0 at distance from anal verge ≤ 8cm, who received curative radical resection. Results The study included 279 patients with pT1/pT2N0 mid-low rectal cancer with median follow-up of 73.5 months. Nineteen (6.8%) patients had disease recurrence in total. Nine (3.2%) of them had local recurrence, and fourteen (5.0%) of them had distant metastasis. Distal resection margin < 0.9 (cm) (hazard ratio = 4.9, p = 0.050) was the risk factor of local recurrence. Preoperative carcinoembryonic antigen (CEA) ≥ 5 ng/mL (hazard ratio = 9.3, p = 0.0003), lymph node yield (LNY) < 14 (hazard ratio = 5.0, p = 0.006), and distal resection margin < 1.4cm (hazard ratio = 4.0, p = 0.035) were the risk factors of distant metastasis. Conclusion For patients with pT1/pT2N0 mid-low rectal cancer, current multidisciplinary treatment brings acceptable survival outcome. Insufficient distal resection margin attracted the awareness of risk factors for local recurrence and distant metastasis as a foundation for future research.

• Publisher: BioMed Central,BMC
• Subject: Adenocarcinoma / Antigens / Cancer / Cancer therapies / Carcinoembryonic antigen / Colorectal cancer / Current Evidence and Future Directions in the Treatment of Colorectal Cancer / Distant metastasis / Health hazards / Humans / Local recurrence / Lymph nodes / Medicine / Medicine & Public Health / Metastases / Metastasis / Neoplasm Recurrence, Local - epidemiology / Neoplasm Recurrence, Local - surgery / Neoplasm Staging / Ostomy / Patients / Prenatal development / Prognosis / Quality of life / Radiation therapy / Radical resection / Rectal cancer / Rectal Neoplasms - pathology / Rectal Neoplasms - surgery / Rectum / Retrospective Studies / Risk analysis / Risk Factors / Surgery / Surgical Oncology / Survival analysis / Total mesorectal excision / Treatment Outcome