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Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming
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Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming
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Journal Article
Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming
2020
Overview
Pathogens utilize multiple types of effectors to modulate plant immunity. Although many apoplastic and cytoplasmic effectors have been reported, nuclear effectors have not been well characterized in fungal pathogens. Here, we characterize two nuclear effectors of the rice blast pathogen
Magnaporthe oryzae
. Both nuclear effectors are secreted via the biotrophic interfacial complex, translocated into the nuclei of initially penetrated and surrounding cells, and reprogram the expression of immunity-associated genes by binding on effector binding elements in rice. Their expression in transgenic rice causes ambivalent immunity: increased susceptibility to
M
.
oryzae
and
Xanthomonas oryzae
pv.
oryzae
, hemibiotrophic pathogens, but enhanced resistance to
Cochliobolus miyabeanus
, a necrotrophic pathogen. Our findings help remedy a significant knowledge deficiency in the mechanism of
M
.
oryzae
–rice interactions and underscore how effector-mediated manipulation of plant immunity by one pathogen may also affect the disease severity by other pathogens.
Plant pathogens secrete various effectors to manipulate host immunity. Here, Kim et al. describe two
Magnaporthe oryzae
effectors that translocate into the nuclei of infected rice cells and reprogram expression of immunity-associated genes, increasing susceptibility to hemibiotrophic pathogens.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/35
/ 38/77
/ 38/88
/ 42/35
/ Binding
/ Fungal Proteins - metabolism
/ Fungi
/ Gene Expression Regulation, Fungal
/ Gene Expression Regulation, Plant
/ Genes
/ Host-Pathogen Interactions - genetics
/ Host-Pathogen Interactions - immunology
/ Humanities and Social Sciences
/ Immunity
/ Plant Diseases - microbiology
/ Plants, Genetically Modified
/ Science
