Asset Details
Do you wish to reserve the book?
Perirenal adipose afferent nerves sustain pathological high blood pressure in rats
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Perirenal adipose afferent nerves sustain pathological high blood pressure in rats
Do you wish to request the book?
Perirenal adipose afferent nerves sustain pathological high blood pressure in rats
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Perirenal adipose afferent nerves sustain pathological high blood pressure in rats
2022
Overview
Hypertension is a pathological condition of persistent high blood pressure (BP) of which the underlying neural mechanisms remain obscure. Here, we show that the afferent nerves in perirenal adipose tissue (PRAT) contribute to maintain pathological high BP, without affecting physiological BP. Bilateral PRAT ablation or denervation leads to a long-term reduction of high BP in spontaneous hypertensive rats (SHR), but has no effect on normal BP in control rats. Further, gain- and loss-of-function and neuron transcriptomics studies show that augmented activities and remodeling of L1-L2 dorsal root ganglia neurons are responsible for hypertension in SHR. Moreover, we went on to show that calcitonin gene-related peptide (CGRP) is a key endogenous suppressor of hypertension that is sequestered by pro-hypertensive PRAT in SHRs. Taken together, we identify PRAT afferent nerves as a pro-hypertensive node that sustains high BP via suppressing CGRP, thereby providing a therapeutic target to tackle primary hypertension.
The sympathetic nervous system can contribute to the development of hypertension, but the neurogenic mechanisms involved are incompletely understood. Here the authors report that afferent nerves in the perirenal adipose tissue (PRAT) contribute to the maintenance of high blood pressure, and PRAT ablation, denervation or upregulation of calcitonin gene-related peptide reduce blood pressure in hypertensive rats.
