Asset Details
Do you wish to reserve the book?
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
Do you wish to request the book?
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
2017
Overview
Jumonji (JmjC) domain proteins influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome. JmjC proteins have been associated with many human diseases including various cancers, developmental and neurological disorders, however, the shared biology and possible common contribution to organismal development and tissue homeostasis of all JmjC proteins remains unclear. Here, we systematically tested the function of all 13
Drosophila JmjC
genes. Generation of molecularly defined null mutants revealed that loss of 8 out of 13
JmjC
genes modify position effect variegation (PEV) phenotypes, consistent with their ascribed role in regulating chromatin organization. However, most
JmjC
genes do not critically regulate development, as 10 members are viable and fertile with no obvious developmental defects. Rather, we find that different
JmjC
mutants specifically alter the phenotypic outcomes in various sensitized genetic backgrounds. Our data demonstrate that, rather than controlling essential gene expression programs,
Drosophila
JmjC proteins generally act to “fine-tune” different biological processes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/44
/ 13/51
/ 13/95
/ 14/19
/ 14/63
/ 38/22
/ 38/23
/ 38/70
/ 42/41
/ 64/24
/ Animals
/ Animals, Genetically Modified - genetics
/ Animals, Genetically Modified - growth & development
/ Animals, Genetically Modified - metabolism
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - growth & development
/ Drosophila melanogaster - metabolism
/ Female
/ Genomes
/ Humanities and Social Sciences
/ Insects
/ Jumonji Domain-Containing Histone Demethylases - genetics
/ Jumonji Domain-Containing Histone Demethylases - metabolism
/ Male
/ Proteins
/ Science
