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Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy
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Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy
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Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy
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Journal Article
Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy
2016
Overview
Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The
in vitro
and
in vivo
experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.
Black phosphorus is a biodegradable 2D material that has attracted growing interest in biomedicine. Here, the authors carry out
in vitro
and
in vivo
experiments to demonstrate that nanospheres loaded with black-phosphorus quantum dots perform as promising phothermal cancer therapy agents.
