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Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice
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Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice
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Journal Article
Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice
2017
Overview
Mitochondria are essential organelles to efficiently produce ATP by ATP-synthase, which uses a proton-gradient generated by respiratory chain complexes. We previously demonstrated that COX7RP/COX7A2L/SCAF1 is a key molecule that promotes respiratory supercomplex assembly and regulates energy generation. The contribution of COX7RP to metabolic homeostasis, however, remains to be clarified. In the present study, we showed a metabolic phenotype of
Cox7rp
knockout (
Cox7rp
KO) mice, which exhibit lower blood glucose levels after insulin or pyruvate injection. Notably, ATP synthesis rate was reduced in
Cox7rp
KO mice liver, in accordance with decreased percentages of complex III subunit RISP and complex IV subunit COX1 involved in I + III + IV supercomplex fraction. The present findings suggest that COX7RP-mediated mitochondrial respiration plays crucial roles in the regulation of glucose homeostasis and its impairment will lead to the pathophysiology of metabolic states.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/77
/ 631/45
/ 64/110
/ 82/29
/ Adenosine Triphosphate - biosynthesis
/ Animals
/ Blood
/ Electron Transport Complex IV - genetics
/ Electron Transport Complex IV - metabolism
/ Glucose
/ Humanities and Social Sciences
/ Insulin
/ Liver
/ Male
/ Mice
/ Mitochondrial Membranes - chemistry
/ Mitochondrial Membranes - metabolism
/ Scavenger Receptors, Class A - genetics
/ Scavenger Receptors, Class A - metabolism
/ Science
