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Man-made microbial resistances in built environments
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Journal Article
Man-made microbial resistances in built environments
2019
Overview
Antimicrobial resistance is a serious threat to global public health, but little is known about the effects of microbial control on the microbiota and its associated resistome. Here we compare the microbiota present on surfaces of clinical settings with other built environments. Using state-of-the-art metagenomics approaches and genome and plasmid reconstruction, we show that increased confinement and cleaning is associated with a loss of microbial diversity and a shift from Gram-positive bacteria, such as
Actinobacteria
and
Firmicutes
, to Gram-negative such as
Proteobacteria
. Moreover, the microbiome of highly maintained built environments has a different resistome when compared to other built environments, as well as a higher diversity in resistance genes. Our results highlight that the loss of microbial diversity correlates with an increase in resistance, and the need for implementing strategies to restore bacterial diversity in certain built environments.
The environmental microbiota can have important implications for our well-being. Here, the authors describe the composition of microbiomes from diverse buildings, including samples from clinical environments, and show that cleaner environments are associated with a loss of microbial diversity and an increase in genes associated with antibiotic resistance.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/29
/ 45/41
/ 45/77
/ 49/23
/ 49/40
/ Bacteria
/ Drug Resistance, Microbial - genetics
/ Genomes
/ Gram-Negative Bacteria - drug effects
/ Gram-Negative Bacteria - genetics
/ Gram-Negative Bacteria - isolation & purification
/ Gram-Positive Bacteria - drug effects
/ Gram-Positive Bacteria - genetics
/ Gram-Positive Bacteria - isolation & purification
/ Humanities and Social Sciences
/ Humans
/ Science
