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Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
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Journal Article
Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
2019
Overview
Many traits vary among isogenic individuals in homogeneous environments. In microbes, plants and animals, variation in the protein chaperone system affects many such traits. In the animal model
C. elegans
, the expression level of
hsp-16.2
chaperone biomarkers correlates with or predicts the penetrance of mutations and lifespan after heat shock. But the physiological mechanisms causing cells to express different amounts of the biomarker were unknown. Here, we used an in vivo microscopy approach to dissect different contributions to cell-to-cell variation in
hsp-16.2
expression in the intestines of young adult animals, which generate the most lifespan predicting signal. While we detected both cell autonomous intrinsic noise and signaling noise, we found both contributions were relatively unimportant. The major contributor to cell-to-cell variation in biomarker expression was general differences in protein dosage. The
hsp-16.2
biomarker reveals states of high or low effective dosage for many genes.
In
C. elegans
the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/35
/ 64/11
/ Animals
/ Animals, Genetically Modified
/ Caenorhabditis elegans - physiology
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Heat-Shock Proteins - genetics
/ Heat-Shock Proteins - metabolism
/ Humanities and Social Sciences
/ Intravital Microscopy - methods
/ Luminescent Proteins - genetics
/ Luminescent Proteins - metabolism
/ Microscopy, Fluorescence - methods
/ Mutation
/ Science
