Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

by Ichikawa, Tomohiko , Takahashi, Satoru , Nakanishi, Hayao , Ota, Hayato , Sakamoto, Shinichi , Ikeda, Jun-Ichiro , Nishihara, Shoko , Yamada, Shuhei , Sato, Hirokazu , Wakai, Ken , Mizumoto, Shuji , Yamamoto, Kazuo , Ikehara, Yuzuru , Yoneda, Kei

in 631/337/458/1524 / 631/45/221 / Androgens / Anticoagulants / Castration / Cell activation / Cell growth / Cell proliferation / Cell surface / Epidermal growth factor / Epidermal growth factor receptors / Extracellular signal-regulated kinase / Gefitinib / Glycosaminoglycans / Heparan sulfate / Humanities and Social Sciences / Inhibitor drugs / Ligands / Medicine / multidisciplinary / Pathology / Phosphorylation / Prostate cancer / Science / Science (multidisciplinary) / Signal transduction / Sulfates / Sulfotransferase

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

2023

Confirm

Do you wish to request the book?

Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

Ichikawa, Tomohiko,

Takahashi, Satoru,

Nakanishi, Hayao,

Ota, Hayato,

Sakamoto, Shinichi,

Ikeda, Jun-Ichiro,

Nishihara, Shoko,

Yamada, Shuhei,

Sato, Hirokazu,

Wakai, Ken,

Mizumoto, Shuji,

Yamamoto, Kazuo,

Ikehara, Yuzuru,

Yoneda, Kei

2023

Overview

Androgen deprivation therapy is given to suppress prostate cancer growth; however, some cells continue to grow hormone-independently as castration-resistant prostate cancer (CRPC). Sulfated glycosaminoglycans promote ligand binding to receptors as co-receptors, but their role in CRPC remains unknown. Using the human prostate cancer cell line C4-2, which can proliferate in hormone-dependent and hormone-independent conditions, we found that epidermal growth factor (EGF)-activated EGFR–ERK1/2 signaling via 3- O -sulfated heparan sulfate (HS) produced by HS 3- O -sulfotransferase 1 (HS3ST1) is activated in C4-2 cells under hormone depletion. Knockdown of HS3ST1 in C4-2 cells suppressed hormone-independent growth, and inhibited both EGF binding to the cell surface and activation of EGFR–ERK1/2 signaling. Gefitinib, an EGFR inhibitor, significantly suppressed C4-2 cell proliferation and growth of a xenografted C4-2 tumor in castrated mouse. Collectively, our study has revealed a mechanism by which cancer cells switch to hormone-independent growth and identified the key regulator as 3- O -sulfated HS.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject