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The Clinical Course of Acute Kidney Disease after Cardiac Surgery: A Retrospective Observational Study
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The Clinical Course of Acute Kidney Disease after Cardiac Surgery: A Retrospective Observational Study
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Journal Article
The Clinical Course of Acute Kidney Disease after Cardiac Surgery: A Retrospective Observational Study
2020
Overview
Acute kidney disease (AKD), or renal dysfunction persisting >7 days after an initiating event of acute kidney injury, is a rising concern. This study aimed to elucidate the clinical course of AKD after cardiac surgery with data on post-cardiac surgery patients admitted to intensive care units (ICU) at 18 Japanese hospitals during 2012–2014. Using multivariable logistic models, we evaluated the association of AKD with 90-day mortality and the 50% eGFR decline during 2-year follow-up compared to eGFR at 90 days. AKD was defined as an elevation in serum creatinine to at least 1.5-fold from baseline in >7 days after ICU admission. Of the 3,605 eligible patients undergoing cardiac surgery, 403 patients (11.2%) had AKD. Multivariable analysis revealed that the adjusted odds ratio (OR) of AKD for 90-day mortality was 63.0 (95% confidence interval [CI], 27.9–180.6). In addition, the adjusted OR of AKD for 50% eGFR decline was 3.56 (95% CI, 2.24–5.57) among hospital survivors. In conclusion, AKD after cardiac surgery was associated with higher 90-day mortality and renal function decline after hospital discharge.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group
Subject
/ Acute Kidney Injury - epidemiology
/ Acute Kidney Injury - etiology
/ Acute Kidney Injury - physiopathology
/ Aged
/ Cardiac Surgical Procedures - adverse effects
/ Epidermal growth factor receptors
/ Female
/ Glomerular Filtration Rate - physiology
/ Humanities and Social Sciences
/ Humans
/ Intensive Care Units - statistics & numerical data
/ Kidney
/ Kidneys
/ Male
/ Patients
/ Postoperative Complications - blood
/ Postoperative Complications - epidemiology
/ Postoperative Complications - etiology
/ Postoperative Complications - physiopathology
/ Science
