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High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity
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High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity
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High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity
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Journal Article
High concentrations of environmental ammonia induced changes in large‐scale loach (Paramisgurnus dabryanus) immunity
2021
Overview
High concentrations of environmental ammonia can cause reduced immunity and death in fish, causing enormous economic losses. Air‐breathing fish usually have a high ammonia tolerance and are very suitable for high‐density fish farming. However, research on the effects of environmental ammonia on air‐breathing fish immunity is lacking. Therefore, this study investigated the effects of environmental ammonia on the immunity of large‐scale loach (Paramisgurnus dabryanus) by exposing fish to 30 mmol/L NH4Cl solution and subsequently analyzing the changes in serum and liver immune indicators, including total protein, albumin, globulin, immunoglobulin (Ig) M, lysozyme, complement component (C) 3 and C4, heat shock protein (HSP) 70, HSP90, tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, and IL‐12. Results revealed that ammonia exposure significantly affected the total protein, albumin, globulin, IgM, complement C3 and C4, HSP70, HSP90, and inflammatory cytokine contents in the body, indicating that ammonia exposure induced a significant immune response and lowered bodily immunity. However, most of the immune indicators significantly decreased in the later stages of the experiment, suggesting a weakened immune response, which may be due to the species‐specific ammonia detoxification ability of large‐scale loach that reduces ammonia toxicity in the body. This study demonstrated the effects of high concentration of environmental ammonia on the immune response in Paramisgurnus dabryanus. Species‐specific ammonia detoxification strategies in P. dabryanus could weaken the immune response induced by high environmental ammonia.
