Journal Article

Low rate of severe-end-stage kidney disease after SABR for localised primary kidney cancer

Eapen, Renu, Chan, Phil, Siva, Shankar, Oon, Sheng F., Ali, Muhammad, Moon, Daniel, Lawrentschuk, Nathan, Hardcastle, Nicholas, Murphy, Declan G., Koo, Kendrick, Chander, Sarat, Goad, Jeremy, Shaw, Mark, Azad, Arun A., Chang, David

2024

Overview

Background Stereotactic ablative body radiotherapy (SABR) is an emerging treatment for patients with primary renal cell carcinoma (RCC). However, its impact on renal function is unclear. This study aimed to evaluate incidence and clinical factors predictive of severe to end-stage chronic kidney disease (CKD) after SABR for RCC. Methods and materials This was a Single institutional retrospective analysis of patients with diagnosed primary RCC receiving SABR between 2012–2020. Adult patients with no metastatic disease, baseline estimated glomerular filtration rate (eGFR) of ≥ 30 ml/min/1.73 m 2 , and at least one post-SABR eGFR at six months or later were included in this analysis. Patients with upper tract urothelial carcinoma were excluded. Primary outcome was freedom from severe to end-stage CKD, determined using the Kaplan–Meier estimator. The impact of baseline CKD, age, hypertension, diabetes, tumor size and fractionation schedule were assessed by Cox proportional hazard models. Results Seventy-eight consecutive patients were included, with median age of 77.8 years (IQR 70–83), tumor size of 4.5 cm (IQR 3.9–5.8) and follow-up of 42.2 months (IQR 23–60). Baseline median eGFR was 58 mls/min; 55% (n = 43) of patients had baseline CKD stage 3 and the remainder stage 1–2. By last follow-up, 1/35 (2.8%) of baseline CKD 1–2, 7/27 (25.9%) CKD 3a and 11/16 (68.8%) CKD 3b had developed CKD stage 4–5. The estimated probability of freedom from CKD stage 4–5 at 1 and 5 years was 89.6% (CI 83.0–97.6) and 65% (CI 51.4–81.7) respectively. On univariable analysis, worse baseline CKD ( p  < 0.0001) and multi-fraction SABR ( p  = 0.005) were predictive for development of stage 4–5 CKD though only the former remained significant in multivariable model. Conclusion In this elderly cohort with pre-existing renal dysfunction, SABR achieved satisfactory nephron sparing with acceptable rates of severe to end-stage CKD. It can be an attractive option in patients who are medically inoperable.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Ablation / Adult / Age / Aged / Aged, 80 and over / Analysis / Biomedical and Life Sciences / Biomedicine / Biopsy / Cancer / Cancer Research / Carcinoma, Renal Cell - radiotherapy / Carcinoma, Renal Cell - surgery / Carcinoma, Transitional Cell / Care and treatment / Chronic kidney disease / Chronic kidney failure / Comorbidity / Development and progression / Diabetes / Diabetes mellitus / Diagnosis / End-stage renal disease / Epidermal growth factor receptors / Fractionation / Glomerular filtration rate / Humans / Hypertension / Imaging / Kidney cancer / Kidney diseases / Kidney Failure, Chronic - etiology / Kidney Neoplasms - pathology / Kidney Neoplasms - surgery / Kidneys / Medical imaging / Medical research / Medicine, Experimental / Metastases / Oncology / Patient outcomes / Patients / Prevention / Radiation therapy / Radiology / Radiosurgery / Radiosurgery - adverse effects / Radiosurgery - methods / Radiotherapy / RCC / Renal cell carcinoma / Renal function / Renal Insufficiency, Chronic - etiology / Retrospective Studies / Risk factors / SABR / Statistical models / Stereotactic ablative radiotherapy / Toxicity / Tumors / Urinary Bladder Neoplasms / Urological cancer / Urothelial carcinoma