Journal Article

Association of sleep duration in middle and old age with incidence of dementia

Singh-Manoux, Archana, Kivimäki, Mika, Hôpital Lariboisière-Fernand-Widal [APHP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sabia, Séverine, Dumurgier, Julien, Dugravot, Aline, Epidemiology of Ageing and Neurodegenerative diseases (EpiAgeing [CRESS - U1153 / UMR_A 1125]) ; Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Camden and Islington NHS Foundation Trust [Londres, Royaume-Uni] (C&I), ANR-19-CE36-0004,ActivHealth,Rôle de l'intensité, de la durée et des profils d'activité physique mesurés par accéléromètres pour la santé

2021

Overview

Abstract Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01–1.48), 1.37 (1.10–1.72), and 1.24 (0.98–1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 692/499 / 692/617/375/132 / 692/700/478/174 / Adult / Age / Age Factors / Aged / Aged, 80 and over / Cohort Studies / Confidence intervals / Dementia / Dementia - epidemiology / Dementia - etiology / Dementia - physiopathology / Dementia disorders / Ecology, environment / Female / Follow-Up Studies / Health / Humanities and Social Sciences / Humans / Incidence / Life Sciences / Longitudinal Studies / Male / Mental health / Middle Aged / multidisciplinary / Proportional Hazards Models / Risk / Risk Factors / Science / Science (multidisciplinary) / Sleep / Sleep - physiology / Sleep deprivation / Sleep Deprivation - complications / Sleep Deprivation - physiopathology / Sleep Wake Disorders - complications / Sleep Wake Disorders - physiopathology / Time Factors / United Kingdom - epidemiology