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HiChIP: efficient and sensitive analysis of protein-directed genome architecture
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HiChIP: efficient and sensitive analysis of protein-directed genome architecture
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Journal Article
HiChIP: efficient and sensitive analysis of protein-directed genome architecture
2016
Overview
HiChIP combines chromosome conformation capture with immunoprecipitation- and tagmentation-based library preparation to uncover the 3D chromatin architecture focused around a protein of interest.
Genome conformation is central to gene control but challenging to interrogate. Here we present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of conformation-informative reads by over 10-fold and lowers the input requirement over 100-fold relative to that of ChIA-PET. HiChIP of cohesin reveals multiscale genome architecture with greater signal-to-background ratios than those of
in situ
Hi-C.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biomedical Engineering/Biotechnology
/ Cell Cycle Proteins - chemistry
/ Cell Cycle Proteins - genetics
/ Cell Cycle Proteins - metabolism
/ Chromatin Immunoprecipitation - methods
/ Chromosomal Proteins, Non-Histone - chemistry
/ Chromosomal Proteins, Non-Histone - genetics
/ Chromosomal Proteins, Non-Histone - metabolism
/ Cohesins
/ Embryonic Stem Cells - metabolism
/ Genes
/ Genomes
/ Genomics
/ Humans
/ Mice
/ Proteins
