Asset Details
Do you wish to reserve the book?
Automated opportunistic osteoporotic fracture risk assessment using computed tomography scans to aid in FRAX underutilization
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Automated opportunistic osteoporotic fracture risk assessment using computed tomography scans to aid in FRAX underutilization
Do you wish to request the book?
Automated opportunistic osteoporotic fracture risk assessment using computed tomography scans to aid in FRAX underutilization
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Automated opportunistic osteoporotic fracture risk assessment using computed tomography scans to aid in FRAX underutilization
2020
Overview
Methods for identifying patients at high risk for osteoporotic fractures, including dual-energy X-ray absorptiometry (DXA)
1
,
2
and risk predictors like the Fracture Risk Assessment Tool (FRAX)
3
–
6
, are underutilized. We assessed the feasibility of automatic, opportunistic fracture risk evaluation based on routine abdomen or chest computed tomography (CT) scans. A CT-based predictor was created using three automatically generated bone imaging biomarkers (vertebral compression fractures (VCFs), simulated DXA T-scores and lumbar trabecular density) and CT metadata of age and sex. A cohort of 48,227 individuals (51.8% women) aged 50–90 with available CTs before 2012 (index date) were assessed for 5-year fracture risk using FRAX with no bone mineral density (BMD) input (FRAXnb) and the CT-based predictor. Predictions were compared to outcomes of major osteoporotic fractures and hip fractures during 2012–2017 (follow-up period). Compared with FRAXnb, the major osteoporotic fracture CT-based predictor presented better receiver operating characteristic area under curve (AUC), sensitivity and positive predictive value (PPV) (+1.9%, +2.4% and +0.7%, respectively). The AUC, sensitivity and PPV measures of the hip fracture CT-based predictor were noninferior to FRAXnb at a noninferiority margin of 1%. When FRAXnb inputs are not available, the initial evaluation of fracture risk can be done completely automatically based on a single abdomen or chest CT, which is often available for screening candidates
7
,
8
.
A retrospective analysis of existing computed tomography scans shows the feasibility of an automated process for evaluating osteoporotic fracture risk that could be used as an initial screening tool when FRAX inputs are unavailable.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 692/499
/ Abdomen
/ Aged
/ Biomedical and Life Sciences
/ Chest
/ Complications and side effects
/ Dual energy X-ray absorptiometry
/ Female
/ Fractures, Compression - diagnosis
/ Fractures, Compression - diagnostic imaging
/ Hip
/ Hip Fractures - diagnostic imaging
/ Humans
/ Letter
/ Male
/ Osteoporotic Fractures - diagnosis
/ Osteoporotic Fractures - diagnostic imaging
/ Spinal Fractures - diagnosis
