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Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus
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Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus
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Journal Article
Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus
2018
Overview
Background
Large scale association studies have found a significant association between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as the studies report inconsistent results in different populations. Hence, we perform this meta-analysis to give a more convincing result.
Methods
The articles, published from January 1st, 2000 to April 1st, 2017, were identified by searching in PubMed and Google Scholar. A total of 56628 participants (34232 cases and 22396 controls) were included in the meta-analysis. A total of 28 studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 studies), South Asian (5 studies) and Others (8 studies). All the data analyses were analyzed by the R package meta.
Results
The significant association was observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47,
p
< 0.0001), recessive model (OR = 1.58, CI = 1.48 - 1.69,
p
< 0.0001), additive model(CT vs CC) (OR = 1.34, CI = 1.28-1.39,
p
< 0.0001), additive model(TT vs CC) (OR = 1.81, CI = 1.69-1.94,
p
< 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39,
p
< 0.0001).
Conclusion
The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Biomedical and Life Sciences
/ Cellular signal transduction
/ Diabetes Mellitus, Type 2 - diagnosis
/ Diabetes Mellitus, Type 2 - genetics
/ Genetic epidemiology and genetic associations
/ Genetic Predisposition to Disease
/ Humans
/ Polymorphism, Single Nucleotide
/ T2DM
