Asset Details
Do you wish to reserve the book?
Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer
Do you wish to request the book?
Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer
2018
Overview
The human intestine retains a complex microbial ecosystem, which performs crucial functions that impact on host health. Several studies have indicated that intestinal dysbiosis may impact on the establishment of life-threatening intestinal diseases such as colorectal cancer. An adenomatous polyp is the result of abnormal tissue growth, which is benign but is considered to be associated with a high risk of developing colorectal cancer, based on its grade of dysplasia. Development of diagnostic tools that are based on surveying the gut microbiota and are aimed at early detection of colorectal cancer represent highly desirable target. For this purpose, we performed a pilot study in which we applied a metataxonomic analysis based on 16S rRNA gene sequencing approach to unveil the composition of microbial communities of intestinal polyps. Moreover, we performed a meta-analysis involving the reconstructed microbiota composition of adenomatous polyps and publicly available metagenomics datasets of colorectal cancer. These analyses allowed the identification of microbial taxa such as
Faecalibacterium
,
Bacteroides
and
Romboutsia
, which appear to be depleted in cancerogenic mucosa as well as in adenomatous polyps, thus representing novel microbial biomarkers associated with early tumor formation. Furthermore, an absolute quantification of
Fusubacterium nucleatum
in polyps further compounded the important role of this microorganism as a valuable putative microbial biomarker for early diagnosis of colorectal cancer.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adenomatous Polyps - diagnosis
/ Adenomatous Polyps - genetics
/ Adenomatous Polyps - microbiology
/ Aged
/ Bacteria - isolation & purification
/ Colorectal Neoplasms - diagnosis
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - microbiology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Intestinal Polyps - diagnosis
/ Intestinal Polyps - genetics
/ Intestinal Polyps - microbiology
/ Male
/ Mucosa
/ Mucous Membrane - metabolism
/ Mucous Membrane - microbiology
/ Physics
/ Polyps
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Science
