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Translational control of immune responses: from transcripts to translatomes
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Journal Article
Translational control of immune responses: from transcripts to translatomes
2014
Overview
Translation of mRNA is controlled by a whole host of tightly regulated processes. In this Focus Review, Piccirillo
et al
. describe how translational skewing can serve a key role in the immune system.
Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent. Studies of 'translatomes' (genome-wide pools of translated mRNA) have facilitated mechanistic discoveries by identifying key regulatory components, including transcription factors, that are under translational control. Here we review the current knowledge on mechanisms that regulate translation and thereby modulate immunological function. We further describe approaches for measuring and analyzing translatomes and how such powerful tools can facilitate future insights on the role of translational control in the immune system.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adaptor Proteins, Signal Transducing - genetics
/ Adaptor Proteins, Signal Transducing - immunology
/ Animals
/ Eukaryotic Initiation Factor-4E - genetics
/ Eukaryotic Initiation Factor-4E - immunology
/ Gene Expression Regulation - genetics
/ Humans
/ Mechanistic Target of Rapamycin Complex 1
/ Mice
/ Multiprotein Complexes - genetics
/ Phosphoproteins - immunology
/ Protein Biosynthesis - genetics
/ Protein Biosynthesis - immunology
