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Acetaminophen, Aspirin, and Chronic Renal Failure
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Acetaminophen, Aspirin, and Chronic Renal Failure
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Acetaminophen, Aspirin, and Chronic Renal Failure
Acetaminophen, Aspirin, and Chronic Renal Failure
Journal Article

Acetaminophen, Aspirin, and Chronic Renal Failure

2001
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Overview
Epidemiologic studies have linked the use of nonnarcotic analgesics with the development of chronic renal failure, yet whether this relation is causal has been unclear. This nationwide, population-based, case–control study of early-stage chronic renal insufficiency in Sweden found that the regular use of either aspirin or acetaminophen increases the risk of chronic renal failure by a factor of 2.5. Analgesic nephropathy, first attributed to the habitual use of phenacetin-containing analgesics, 1 , 2 has also been described among users of excessive amounts of analgesic mixtures containing acetaminophen (paracetamol), aspirin, caffeine, or codeine. 3 , 4 The use of single-ingredient analgesics containing acetaminophen or aspirin has also been linked with chronic renal failure. 5 – 8 Previous case–control studies evaluating analgesic use in relation to chronic renal failure have had methodologic shortcomings, 9 – 12 including a failure to identify patients early enough in the course of their disease to ensure that the disease itself had not led to a change in the use of analgesics; a failure . . .