Journal Article

Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids

Li, Huifei, Li, Na, Wang, Xing, Zhao, Xiangyu, Wang, Jia, Zhang, Xiaoxuan, Hong, Jinjia, Xie, Qingpeng, Zhang, Ziqi, Zhang, Yuan, Zhang, Pengfei, Ren, Xiuyun, Hao, Yujia, Liu, Meixian

2024

Overview

Bone defects pose significant challenges in healthcare, with over 2 million bone repair surgeries performed globally each year. As a burgeoning force in the field of bone tissue engineering, 3D printing offers novel solutions to traditional bone transplantation procedures. However, current 3D-printed bone scaffolds still face three critical challenges in material selection, printing methods, cellular self-organization and co-culture, significantly impeding their clinical application. In this comprehensive review, we delve into the performance criteria that ideal bone scaffolds should possess, with a particular focus on the three core challenges faced by 3D printing technology during clinical translation. We summarize the latest advancements in non-traditional materials and advanced printing techniques, emphasizing the importance of integrating organ-like technologies with bioprinting. This combined approach enables more precise simulation of natural tissue structure and function. Our aim in writing this review is to propose effective strategies to address these challenges and promote the clinical translation of 3D-printed scaffolds for bone defect treatment. Graphical abstract

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: 3D printing / Animals / Artificial organs / Biomedical materials / Bioprinting - methods / Biotechnology / Bone and Bones / Bone diseases / Bone Regeneration / Bone scaffolds / Bone Transplantation - methods / Care and treatment / Chemistry / Chemistry and Materials Science / Clinical translation / Equipment and supplies / Humans / Methods / Molecular Medicine / Nanotechnology / Organoids / Organoids - cytology / Orthopedic surgery / Printing materials / Printing methods / Printing, Three-Dimensional / Production processes / Review / Tissue engineering / Tissue Engineering - methods / Tissue Scaffolds - chemistry