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Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function
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Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function
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Journal Article
Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function
2020
Overview
During vertebrate development, the presomitic mesoderm (PSM) periodically segments into somites, which will form the segmented vertebral column and associated muscle, connective tissue, and dermis. The periodicity of somitogenesis is regulated by a segmentation clock of oscillating Notch activity. Here, we examined mouse mutants lacking only
Fgf4
or
Fgf8
, which we previously demonstrated act redundantly to prevent PSM differentiation.
Fgf8
is not required for somitogenesis, but
Fgf4
mutants display a range of vertebral defects. We analyzed
Fgf4
mutants by quantifying mRNAs fluorescently labeled by hybridization chain reaction within Imaris-based volumetric tissue subsets. These data indicate that FGF4 maintains
Hes7
levels and normal oscillatory patterns. To support our hypothesis that FGF4 regulates somitogenesis through
Hes7
, we demonstrate genetic synergy between
Hes7
and
Fgf4
, but not with
Fgf8
. Our data indicate that
Fgf4
is potentially important in a spectrum of human Segmentation Defects of the Vertebrae caused by defective Notch oscillations.
Publisher
eLife Science Publications, Ltd,eLife Sciences Publications, Ltd,eLife Sciences Publications Ltd
Subject
/ Animals
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Basic Helix-Loop-Helix Transcription Factors - metabolism
/ Fibroblast Growth Factor 4 - genetics
/ Fibroblast Growth Factor 4 - metabolism
/ Fibroblast Growth Factor 8 - genetics
/ Fibroblast Growth Factor 8 - metabolism
/ Gene Expression Regulation, Developmental - physiology
/ hybridization chain reaction
/ Mice
/ Mutation
/ Notch
