Journal Article

Global burden, risk factors, and temporal trends of ureteral cancer: a comprehensive analysis of cancer registries

Teoh, Jeremy Yuen-Chun, Mak, Fung Yu, Fung, Yat Ching, Huang, Junjie, Chan, Sze Chai, Zhang, Lin, Xu, Wanghong, Soria, Francesco, Lucero-Prisno, Don Eliseo, Ng, Anthony Chi-Fai, Liu, Xianjing, Moschini, Marco, Roupret, Morgan, Shariat, Shahrokh, Wong, Martin C. S., Pradere, Benjamin, Pang, Wing Sze, Zheng, Zhi-Jie, Enikeev, Dmitry

2024

Overview

Background Ureteral cancer is a rare cancer. This study aimed to provide an up-to-date and comprehensive analysis on the global trends of ureteral cancer incidence and its association with lifestyle and metabolic risk factors. Methods The incidence of ureteral cancer was estimated from the Cancer Incidence in Five Continents Plus and Global Cancer Observatory databases. We analyzed the (1) global incidence of ureteral cancer by region, country, sex, and age group by age-standardized rates (ASR); (2) associated risk factors on a population level by univariable linear regression with logarithm transformation; and (3) incidence trend of ureteral cancer by sex and age group in different countries by Average Annual Percentage Change (AAPC). Results The global age-standardized rate of ureteral cancer incidence in 2022 was 22.3 per 10,000,000 people. Regions with higher human development index (HDI), such as Europe, Northern America, and East Asia, were found to have a higher incidence of ureteral cancer. Higher HDI and gross domestic product (GDP) and a higher prevalence of smoking, alcohol drinking, physical inactivity, unhealthy dietary, obesity, hypertension, diabetes, and lipid disorder were associated with higher incidence of ureteral cancer. An overall increasing trend of ureteral cancer incidence was observed for the past decade, especially among the female population. Conclusions Although ureteral cancer was relatively rare, the number of cases reported was rising over the world. The rising trends among females were more evident compared with the other subgroups, especially in European countries. Further studies could be conducted to examine the reasons behind these epidemiological changes and confirm the relationship with the risk factors identified.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Adult / Age / Age groups / Aged / Aged, 80 and over / Alcohol use / Alcohols / Biomedicine / Cancer / Complications and side effects / Diabetes / Diabetes mellitus / Disease / Diseases / Drinking behavior / Epidemiology / Female / Females / Forecasts and trends / Global Burden of Disease - trends / Global Health / Health aspects / Humans / Hypertension / Incidence / Lipids / Male / Medicine / Medicine & Public Health / Middle Aged / Mortality / Obesity / Oncology, Experimental / Per capita / Population / Registries / Regression analysis / Research Article / Risk analysis / Risk Factors / Sex / Subgroups / Temporal trends / Trends / Ureteral cancer / Ureteral Neoplasms - epidemiology / Ureters / Urinary tract cancer / Urothelial cancer / Young Adult