Asset Details
Do you wish to reserve the book?
High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females
Do you wish to request the book?
High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females
2006
Overview
Ca and P are both essential nutrients for bone and are known to affect one of the most important regulators of bone metabolism, parathyroid hormone (PTH). Too ample a P intake, typical of Western diets, could be deleterious to bone through the increased PTH secretion. Few controlled dose–response studies are available on the effects of high P intake in man. We studied the short-term effects of four P doses on Ca and bone metabolism in fourteen healthy women, 20–28 years of age, who were randomized to four controlled study days; thus each study subject served as her own control. P supplement doses of 0 (placebo), 250, 750 or 1500mg were taken, divided into three doses during the study day. The meals served were exactly the same during each study day and provided 495mg P and 250mg Ca. The P doses affected the serum PTH (S-PTH) in a dose-dependent manner (P=0·0005). There was a decrease in serum ionized Ca concentration only in the highest P dose (P=0·004). The marker of bone formation, bone-specific alkaline phosphatase, decreased (P=0·05) and the bone resorption marker, N-terminal telopeptide of collagen type I, increased in response to the P doses (P=0·05). This controlled dose–response study showed that P has a dose-dependent effect on S-PTH and increases PTH secretion significantly when Ca intake is low. Acutely high P intake adversely affects bone metabolism by decreasing bone formation and increasing bone resorption, as indicated by the bone metabolism markers.
Publisher
Cambridge University Press
Subject
/ Adult
/ adults
/ Alkaline Phosphatase - blood
/ Biological and medical sciences
/ blood
/ calcium
/ Diet
/ dosage
/ Dose-Response Relationship, Drug
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ nutrient-nutrient interactions
/ Peptides
/ Phosphorus - administration & dosage
/ urine
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
/ Vitamin D - analogs & derivatives
/ women
