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Patrolling monocytes control tumor metastasis to the lung

by Metzger, Daniel , Biswas, Subhra K. , Tacke, Robert , Chodaczek, Grzegorz , Thomas, Graham D. , Hedrick, Catherine C. , Rasquinha, Nicole , Cekic, Caglar , Sag, Duygu , Nowyhed, Heba , Wu, Runpei , Hanna, Richard N. , McArdle, Sara , Ichinose, Hiroshi , Peluso, Esther , Herrley, Erica , Shaked, Iftach

in Activation / Animals / Blocking / Cancer / Immune system / Immune systems / Immunologic Surveillance - immunology / Immunology / Immunotherapy / Immunotherapy - methods / Killer Cells, Natural - immunology / Life Sciences / Lung Neoplasms - immunology / Lung Neoplasms - secondary / Lung Neoplasms - therapy / Lungs / Metastasis / Mice / Mice, Mutant Strains / Monocytes - immunology / Neoplasm Invasiveness / Neoplasm Metastasis / Neoplasms, Experimental - immunology / Neoplasms, Experimental - secondary / Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics / Recruitment / Tumors

2015

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2015

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2015

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Journal Article

Patrolling monocytes control tumor metastasis to the lung

Metzger, Daniel,

Biswas, Subhra K.,

Tacke, Robert,

Chodaczek, Grzegorz,

Thomas, Graham D.,

Hedrick, Catherine C.,

Rasquinha, Nicole,

Cekic, Caglar,

Sag, Duygu,

Nowyhed, Heba,

Wu, Runpei,

Hanna, Richard N.,

McArdle, Sara,

Ichinose, Hiroshi,

Peluso, Esther,

Herrley, Erica,

Shaked, Iftach

2015

Overview

The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical \"patrolling\" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)

Subject

/ Animals

/ Cancer

/ Immunologic Surveillance - immunology

/ Immunology

/ Immunotherapy

/ Immunotherapy - methods

/ Killer Cells, Natural - immunology