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C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease
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C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease
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Journal Article
C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease
2017
Overview
This study assesses whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal fluid (CSF) and their potential as biomarkers for Alzheimer’s disease (AD). Immunoprecipitation and simultaneous assay by Western blotting using multiplex fluorescence imaging with specific antibodies against particular domains served to characterize CTFs of APP in human CSF. We demonstrate that APP-CTFs are detectable in human CSF, being the most abundant a 25-kDa fragment, probably resulting from proteolytic processing by η-secretase. The level of the 25-kDa APP-CTF was evaluated in three independent CSF sample sets of patients and controls. The CSF level of this 25-kDa CTF is higher in subjects with autosomal dominant AD linked to
PSEN1
mutations, in demented Down syndrome individuals and in sporadic AD subjects compared to age-matched controls. Our data suggest that APP-CTF could be a potential diagnostic biomarker for AD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 82/1
/ 82/29
/ 82/80
/ Adult
/ Aged
/ Alzheimer Disease - cerebrospinal fluid
/ Alzheimer Disease - complications
/ Alzheimer Disease - pathology
/ Amyloid beta-Protein Precursor - cerebrospinal fluid
/ BETA
/ Biomarkers - cerebrospinal fluid
/ BODIES
/ CELLS
/ Dementia - cerebrospinal fluid
/ Down Syndrome - cerebrospinal fluid
/ Female
/ Humanities and Social Sciences
/ Humans
/ Immunoprecipitation - methods
/ Male
/ Peptide Fragments - cerebrospinal fluid
/ Science
