Journal Article

Muscle weakness in septic patients requiring mechanical ventilation: Protective effect of transcutaneous neuromuscular electrical stimulation

Maskin, Luis P., Attie, Shiry, Valentini, Ricardo, Frosiani, Silvana L., Bonelli, Ignacio, Kozima, Shigeru, Setten, Mariano, Rodriguez, Pablo O., Vidomlansky, Silvana Romero

2012

Overview

The aim of this study was to evaluate the effect of transcutaneous neuromuscular electrical stimulation (NMES) on muscle strength in septic patients requiring mechanical ventilation (MV). Sixteen septic patients requiring MV and having 1 or more organ failure other than respiratory dysfunction were enrolled within 48 hours from admission to the intensive care unit. Neuromuscular electrical stimulation was administered twice a day on brachial biceps and vastus medialis (quadriceps) of 1 side of the body until MV withdrawal. Blinded investigators measured arm and thigh circumferences, biceps thickness by ultrasonography, and muscle strength after awakening with Medical Research Council scale. Two patients died before strength evaluation and were excluded from the analysis. Neuromuscular electrical stimulation was applied for 13 days (interquartile range, 7-30 days). Biceps (P = .005) and quadriceps (P = .034) strengths were significantly higher on the stimulated side at the last day of NMES. Improvement was mainly observed in more severe and weaker patients. Circumference of the nonstimulated arm decreased at the last day of NMES (P = .015), whereas no other significant differences in limb circumferences or biceps thickness were observed. Neuromuscular electrical stimulation was associated with an increase in strength of the stimulated muscle in septic patients requiring MV. Neuromuscular electrical stimulation may be useful to prevent muscle weakness in this population.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Aged / Aged, 80 and over / Arm / Critical Care / Critical illness polyneuropathy / Disease prevention / Electric stimulation / Female / Hospitals / Humans / Intensive care / Male / Middle Aged / Mortality / Multiple organ failure / Multiple Organ Failure - complications / Multiple Organ Failure - rehabilitation / Muscle Strength / Muscle weakness / Muscle Weakness - etiology / Muscle Weakness - prevention & control / Muscular system / Polyneuropathies - etiology / Polyneuropathies - prevention & control / Quadriceps Muscle / Respiration, Artificial / Sepsis / Sepsis - complications / Sepsis - rehabilitation / Single-Blind Method / Studies / Thigh / Transcutaneous Electric Nerve Stimulation / Ventilation