Journal Article

Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®)

Franco, Rossella Di, Gennaro, Davide Di, Manzo, Roberto, Murino, Paola, Anania, Caterina, Ravo, Vincenzo, Calvanese, MariaGrazia, Guida, Cesare

2012

Overview

Introduction This is an observational study and the aim is to evaluate the effect of dietary supplements based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor ® ) in reducing skin toxicity due to external beam radiotherapy in patients affected by breast cancer. Materials and methods 71 patients were enrolled and they were divided in two different groups: a control group (CG) of 41 patients treated with prophylactic topical therapy based on hyaluronic acid and topical steroid therapy in case of occurrence of radiodermatitis, and a Ixor-Group (IG) of 30 patients treated also with an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor ® ) at a dose of 2 tablets/day, starting from 10 days before the radiation treatment until 10 days after the end of treatment. Skin toxicity has been related to PTV, to breast volume that received a radiation dose equal or lower than 107%, included between 107% and 110%, or greater than 110% of the prescribed dose. Moreover it's been studied the relationship between skin toxicity and the chemotherapy schedule used before treatment. We calculated in both groups the percentage of patients who had a skin toxicity of grade 2 or 3 (according to RTOG scale). Absolute risk reduction (ARR), relative risk (RR) and odds ratio (OR) have been calculated for each relationship. Results Control Group (CG) patients with a PTV > 500 ml presented skin toxicity G2 + G3 in 30% of cases, versus 25% of Ixor-Group (IG) [OR 0.77]. In patients with a PTV < 500 ml G2 + G3 toxicity was 0% in the IG compared to 18% in CG (OR 0.23). When Dmax was less than or equal to 107% of the prescribed dose skin toxicity was G2 + G3 in 12.5% in CG, versus 0% in IG (OR 0.73), instead when Dmax was included between 107 and 110% of the prescribed dose, G2 + G3 skin toxicity was 35% in CG and 21% in IG (OR 0.50). In patients undergoing chemotherapy with anthracyclines and taxanes, G2 + G3 toxicity was 27% in CG, against 20% in IG (OR 0.68). Conclusions The protective effect of Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor ® ) is more detected in patients with PTV < 500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Aged / Aged, 80 and over / Anthocyanins - therapeutic use / Antioxidants - therapeutic use / Ascorbic Acid - therapeutic use / Biomedical and Life Sciences / Biomedicine / Breast / Breast cancer / Breast Neoplasms - complications / Breast Neoplasms - radiotherapy / Breasts / Cancer patients / Cancer Research / Cancer therapies / Carotenoids - therapeutic use / Complications and side effects / Dermatitis / Female / Free radicals / Health aspects / Hospitals / Humans / Imaging / Methodology / Middle Aged / Oncology / Prognosis / Radiation therapy / Radiation-Protective Agents - therapeutic use / Radiodermatitis - etiology / Radiodermatitis - prevention & control / Radiology / Radiotherapy / Radiotherapy, Conformal - adverse effects / Risk factors / Skin / Skin diseases / Stilbenes - therapeutic use / Surgery / Toxicity / Vitamin C / Vitamins - therapeutic use