Asset Details
Do you wish to reserve the book?
The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits
Do you wish to request the book?
The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits
2020
Overview
Drosophila melanogaster
is a useful and highly tractable model organism for understanding the molecular mechanisms of human diseases. We previously characterized a new
dUbqn
knockdown model that induces learning-memory and locomotive deficits mediated by impaired proteostasis. Although proteinopathies are the main causes of neurodegenerative diseases, limited information is currently available on the relationship between proteostasis and neurodegenerative-related behavioral perturbations, such as locomotion, wakefulness, and sexual activities. Thus, the present study aimed to elucidate the mechanisms by which
dUbqn
depletion which is known to cause proteinopathies, affects neurodegenerative-related behavioral perturbations. Pan-neuronal
dUbqn
-depleted flies showed significantly reduced evening activity along with altered pre- and postsynaptic structural NMJ’s proteins by attenuating signals of Bruchpilot puncta and GluRIIA clustering. In addition, the neurochemical profiles of GABA, glutamate, dopamine, and serotonin were disturbed and these changes also affected courtship behaviors in
dUbqn
-depleted flies. Collectively, these results extend our understanding on how
dUbqn
depletion affects neurochemical regulation to drive behavioral disturbances that are generally found in the early stage of neurodegenerative diseases. Moreover, the present study may contribute a novel finding to the design of new agents that prevent disease progression or even treat diseases related to neurodegeneration.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/63
/ 64/24
/ 82/1
/ 82/51
/ 82/58
/ Animals
/ Dopamine
/ Drosophila melanogaster - metabolism
/ Drosophila melanogaster - physiology
/ Female
/ gamma-Aminobutyric Acid - metabolism
/ gamma-Aminobutyric Acid - physiology
/ Gas Chromatography-Mass Spectrometry
/ Humanities and Social Sciences
/ Insects
/ Larva
/ Male
/ Nervous System - physiopathology
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - physiopathology
/ Neuromuscular Junction - metabolism
/ Neuromuscular Junction - physiology
/ Science
