Journal Article

Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients

Hifumi, Toru, Sakamoto, Yuichiro, Fujimi, Satoshi, Otomo, Yasuhiro, Gando, Satoshi, Okamoto, Kohji, Ueyama, Masashi, Kotani, Joji, Shiino, Yasukazu, Abe, Toshikazu, Sasaki, Junichi, Tarui, Takehiko, Masuno, Tomohiko, Yamashita, Norio, Ogura, Hiroshi, Nakada, Taka-aki, Ikeda, Hiroto, Shiraishi, Shin-ichiro, Fujishima, Seitaro, Saitoh, Daizoh, Umemura, Yutaka, Shiraishi, Atsushi, Hagiwara, Akiyoshi, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Yamakawa, Kazuma, Mayumi, Toshihiko, Takeyama, Naoshi, Wada, Takeshi, Kushimoto, Shigeki

2021

Overview

Trauma patients die from massive bleeding due to disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype in the early phase, which transforms to DIC with a thrombotic phenotype in the late phase of trauma, contributing to the development of multiple organ dysfunction syndrome (MODS) and a consequently poor outcome. This is a sub-analysis of a multicenter prospective descriptive cross-sectional study on DIC to evaluate the effect of a DIC diagnosis on the survival probability and predictive performance of DIC scores for massive transfusion, MODS, and hospital death in severely injured trauma patients. A DIC diagnosis on admission was associated with a lower survival probability (Log Rank P  < 0.001), higher frequency of massive transfusion and MODS and a higher mortality rate than no such diagnosis. The DIC scores at 0 and 3 h significantly predicted massive transfusion, MODS, and hospital death. Markers of thrombin and plasmin generation and fibrinolysis inhibition also showed a good predictive ability for these three items. In conclusion, a DIC diagnosis on admission was associated with a low survival probability. DIC scores obtained immediately after trauma predicted a poor prognosis of severely injured trauma patients.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 692/308/409 / 692/699/578 / Adult / Aged / Blood Transfusion / Coagulation / Cross-Sectional Studies / Diagnosis / Disseminated intravascular coagulation / Disseminated Intravascular Coagulation - blood / Disseminated Intravascular Coagulation - diagnosis / Disseminated Intravascular Coagulation - etiology / Disseminated Intravascular Coagulation - mortality / Female / Fibrin / Fibrinolysis / Hospital Mortality / Humanities and Social Sciences / Humans / Male / Medical prognosis / Middle Aged / multidisciplinary / Multiple organ dysfunction syndrome / Multiple Organ Failure - etiology / Multiple Organ Failure - mortality / Phenotypes / Plasmin / Prognosis / Prospective Studies / Science / Science (multidisciplinary) / Survival / Thrombin / Transfusion / Trauma / Trauma centers / Wounds and Injuries - blood / Wounds and Injuries - complications / Wounds and Injuries - mortality