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X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes

by Lau, Yee-Ling , Turner, Joseph D. , Mattick, John , Khan, Mohammad Behram , Chung, Matthew , Libro, Silvia , Cook, Darren , Saeung, Atiporn , Kumar, Nikhil , Taylor, Mark J. , Michalski, Michelle , Steven, Andrew , Moorhead, Andrew R. , Chaicumpa, Wanpen , Dunning Hotopp, Julie C. , Sadzewicz, Lisa , Tallon, Luke J. , Sparklin, Benjamin C. , Bromley, Robin , Rao, Ramakrishna , Misra-Bhattacharya, Shailja , Shahab, Mohd , Foster, Jeremy M.

in Adaptability / Animals / Biological diversity / Biology and Life Sciences / Brugia - classification / Brugia - genetics / Cats / Causes of / Chromosome Aberrations / Chromosome abnormalities / Chromosomes / Drug resistance / Ecology and Environmental Sciences / Females / Filariasis / Gene mapping / Genetic aspects / Genetic diversity / Genetic Variation / Genome, Helminth / Genomes / Identification and classification / Laboratories / Nematoda / Nematodes / Nucleotide sequence / Nucleotides / Parasitological research / Population / Populations / Sequencing / Sex chromosomes / Structure / Tropical diseases / X chromosome / X Chromosome - genetics / X chromosomes

2021

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X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes

2021

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X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes

2021

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Journal Article

X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes

Lau, Yee-Ling,

Turner, Joseph D.,

Mattick, John,

Khan, Mohammad Behram,

Chung, Matthew,

Libro, Silvia,

Cook, Darren,

Saeung, Atiporn,

Kumar, Nikhil,

Taylor, Mark J.,

Michalski, Michelle,

Steven, Andrew,

Moorhead, Andrew R.,

Chaicumpa, Wanpen,

Dunning Hotopp, Julie C.,

Sadzewicz, Lisa,

Tallon, Luke J.,

Sparklin, Benjamin C.,

Bromley, Robin,

Rao, Ramakrishna,

Misra-Bhattacharya, Shailja,

Shahab, Mohd,

Foster, Jeremy M.

2021

Overview

The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (π X /π A = 0.2), which is lower than the expected (π X /π A = 0.75). A reduction in diversity is also observed in other filarial nematodes with neo-X chromosome fusions in the genera Onchocerca and Wuchereria , but not those without neo-X chromosome fusions in the genera Loa and Dirofilaria . In the species with neo-X chromosome fusions, chromosome X is abnormally large, containing a third of the genetic material such that a sizable portion of the genome is lacking sequence diversity. Such profound differences in genetic diversity can be consequential, having been associated with drug resistance and adaptability, with the potential to affect filarial eradication.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Adaptability

/ Animals

/ Biological diversity

/ Biology and Life Sciences

/ Brugia - classification

/ Brugia - genetics

/ Cats