Journal Article

Impact of microvasculature invasion subtype (MVI vs. LVI) and associated risk factors on survival outcomes in pancreatic cancer after curative surgery

Zhou, Yuyang, Yu, Jiayin, Bian, Chenyang, Chen, Xiangyi, Li, Huangbao, Zhao, Fengqing

2025

Overview

Objective This study aims to investigate the risk factors associated with microvasculature invasion (MI) in patients with pancreatic cancer and evaluate its prognostic significance. Methods A retrospective analysis was conducted on the clinical data of 288 pancreatic cancer patients who underwent radical pancreatectomy between June 2012 and June 2024. The collected data included demographic characteristics, pathological findings, and laboratory results. Logistic regression analysis was performed to identify potential factors associated with the occurrence of MI. The Kaplan-Meier method was employed to estimate disease-free survival (DFS) and overall survival (OS). Univariate and multivariate Cox proportional hazards regression models were applied to assess the impact of various factors on patient prognosis. Results Among 288 patients, MI was detected in 93 patients (32.3%). Positive microvasculature biomarkers, positive regional lymph nodes (RNP), poor differentiation grade, and reduced MCV might be independent risk factors for MI. Multivariate Cox regression analysis showed that MI, tumor site, RNP, grade, chemotherapy, chloride (Cl) and thrombin time were independent risk factors for DFS and OS. Among 93 patients with MI, no statistically significant difference in prognosis was observed between the MVI and LVI subtypes. Conclusion Positive microvasculature biomarkers, positive RNP, poor histological grade, and reduced MCV levels might serve as independent risk factors for the development of MI. The presence of MI was independent risk factors for DFS and OS. However, no significant prognostic association was observed between the specific origin of invasion (whether MVI or LVI).

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Adult / Aged / Antigens / Biomarkers / Cancer / Cancer invasiveness / Carbohydrates / Cardiovascular tumors / Care and treatment / Chemotherapy / Chi-square test / Clinical outcomes / Data collection / Development and progression / Female / Follow-Up Studies / Hazard assessment / Humans / LVI / Lymph nodes / Lymphatic system / Lymphocytes / Male / Medical prognosis / Medicine / Medicine & Public Health / Metastasis / Microvasculature / Microvasculature invasion / Microvessels - pathology / Middle Aged / Multivariate analysis / MVI / Neoplasm Invasiveness / Neutrophils / Pancreatectomy - mortality / Pancreatic cancer / Pancreatic Neoplasms - mortality / Pancreatic Neoplasms - pathology / Pancreatic Neoplasms - surgery / Patient outcomes / Patients / Prognosis / Prognostic / Regression analysis / Regression models / Retrospective Studies / Risk Factors / Statistical analysis / Surgery / Surgical Oncology / Surgical outcomes / Survival / Survival Rate / Thrombin / Tumors / Variables