Journal Article

Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test

Goita, Seydou, Doumbia, Salif Seriba, Diarra, Dansine, Dolo, Mamadou, Diallo, Abdallah Amadou, Traore, Mamadou Oumar, Guindo, Boubacar, Nutman, Thomas B., Dembele, Benoit, Dembele, Massitan, Dolo, Housseini, Colebunders, Robert, Coulibaly, Siaka Yamoussa, Coulibaly, Michel Emmanuel, Coulibaly, Yaya Ibrahim, Zhang, Yaobi, Dicko, Ilo, Soumaoro, Lamine

2019

Overview

Mali has become increasingly interested in the evaluation of transmission of both Wuchereria bancrofti and Onchocerca volvulus as prevalences of both infections move toward their respective elimination targets. The SD Bioline Onchocerciasis/LF IgG4 Rapid Test was used in 2 evaluation units (EU) to assess its performance as an integrated surveillance tool for elimination of lymphatic filariasis (LF) and onchocerciasis. A cross sectional survey with SD Bioline Onchocerciasis/LF IgG4 Rapid Test was piggy-backed onto a transmission assessment survey (TAS) (using the immunochromatographic card test (ICT) Binax Filariasis Now test for filarial adult circulating antigen (CFA) detection) for LF in Mali among 6-7 year old children in 2016 as part of the TAS in two EUs namely Kadiolo-Kolondieba in the region of Sikasso and Bafoulabe -Kita-Oussoubidiagna-Yelimane in the region of Kayes. In the EU of Kadiolo- Kolondieba, of the 1,625 children tested, the overall prevalence of W. bancrofti CFA was 0.62% (10/1,625) [CI = 0.31-1.09]; while that of IgG4 to Wb123 was 0.19% (3/1,600) [CI = 0.04-0.50]. The number of positives tested with the two tests were statistically comparable (p = 0.09). In the EU of Bafoulabe-Kita-Oussoubidiagna-Yelimane, an overall prevalence of W. bancrofti CFA was 0% (0/1,700) and that of Wb123 IgG4 antibody was 0.06% (1/1,700), with no statistically significant difference between the two rates (p = 0.99). In the EU of Kadiolo- Kolondieba, the prevalence of Ov16-specific IgG4 was 0.19% (3/1,600) [CI = 0.04-0.50]. All 3 positives were in the previously O. volvulus-hyperendemic district of Kolondieba. In the EU of Bafoulabe-Kita-Oussoubidiagna-Yelimane, an overall prevalence of Ov16-specific IgG4 was 0.18% (3/1,700) [CI = 0.04-0.47]. These 3 Ov16 IgG4 positives were from previously O.volvulus-mesoendemic district of Kita. The SD Bioline Onchocerciasis/LF IgG4 Rapid test appears to be a good tool for integrated exposure measures of LF and onchocerciasis in co-endemic areas.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Animals / Antibodies / Antibodies, Helminth - blood / Antibodies, Helminth - immunology / Antigens / Biology and Life Sciences / Care and treatment / Child / Children / Cross-Sectional Studies / Detection / Disease transmission / Elephantiasis, Filarial - blood / Elephantiasis, Filarial - epidemiology / Elephantiasis, Filarial - immunology / Elephantiasis, Filarial - parasitology / Evaluation / Filariasis / Health sciences / Humans / Immunoglobulin G / Immunoglobulin G - blood / Immunoglobulin G - immunology / Immunologic Tests / Infections / Keller, Helen, 1880-1968 / Mali - epidemiology / Medicine / Medicine and Health Sciences / Neglected Diseases - blood / Neglected Diseases - epidemiology / Neglected Diseases - immunology / Neglected Diseases - parasitology / Onchocerca volvulus / Onchocerca volvulus - immunology / Onchocerciasis / Onchocerciasis - blood / Onchocerciasis - epidemiology / Onchocerciasis - immunology / Onchocerciasis - parasitology / People and Places / Polls & surveys / Seroepidemiologic Studies / Serology / Statistical analysis / Surveillance / Surveying / Surveys / Transmission / Tropical diseases / Vector-borne diseases / Wuchereria bancrofti / Wuchereria bancrofti - immunology