Journal Article

A mindfulness-based stress management program for caregivers of allogeneic hematopoietic stem cell transplant (HCT) patients: Protocol for a randomized controlled trial

Yang, Min-Jeong, Brandon, Karen O., Jim, Heather S. L., Gore, L. Robert, Khera, Nandita, Jones, Sarah R., Yepez, Valerie V., Meyer, Jerrold S., Reblin, Maija, Pidala, Joseph, Lau, Penny, Vinci, Christine, Sauls, Rachel M.

2022

Overview

Caregivers of allogeneic hematopoietic stem cell transplant (HCT) cancer patients experience high caregiver burden and carry a significant amount of responsibility. Mindfulness has the potential to lessen caregiver burden by aiding in stress management. To date, no studies have examined the efficacy of mindfulness in reducing caregiver burden in this population. Based on our pilot study demonstrating initial feasibility and acceptability of FOCUS (Focusing On mindfulness for Caregivers Under Stress), this 3-arm randomized controlled trial aims to examine the efficacy of a 6-week mindfulness-based stress management program for allogeneic HCT caregivers. Hypotheses include that the FOCUS condition will have lower post-treatment caregiver burden and that patients of these caregivers will have better patient health outcomes compared to other treatment conditions. Eligible caregivers will be randomly assigned to one of three treatment conditions: FOCUS, Healthy Living (HL; active control), and Enhanced Care (EC; usual care). Caregivers in FOCUS and HL will participate in 6-week weekly individual treatment sessions and will be sent brief daily momentary interventions/messages. Caregivers in all conditions will complete daily diaries over the course of treatment. Patients of enrolled caregivers will be enrolled for assessments only. Participants will complete assessments at baseline, end of treatment, 2- and 6-months post-treatment. Biomarker data will be collected via hair cortisol concentrations from caregivers at baseline and 6 months post-treatment. Recruitment is ongoing. The data collected from this study will provide evidence on the efficacy of mindfulness in alleviating HCT caregiver stress and impacting patient health outcomes. The current study is registered in clinicaltrials.gov (NCT05078229); see https://clinicaltrials.gov/ct2/show/NCT05078229?term=christine+vinci&draw=2&rank=1.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Active control / Assessments / Behavior / Biology and Life Sciences / Biomarkers / Cancer / Care and treatment / Caregivers / Clinical trials / Computer and Information Sciences / Diaries / Engineering and Technology / Feasibility studies / Flexibility / Health aspects / Health services utilization / Hematopoietic Stem Cell Transplantation / Hematopoietic stem cells / Humans / Hydrocortisone / Hypotheses / Informed consent / Intervention / Management / Medicine and Health Sciences / Methods / Mindfulness / Mindfulness - methods / Mindfulness meditation / Patients / Pilot Projects / Psychological aspects / Randomized Controlled Trials as Topic / Research and Analysis Methods / Social Sciences / Stem cell transplantation / Stem cells / Stress / Stress management / Study Protocol / Transplantation / Transplants & implants